Targeting Intrinsic Mechanisms of Antibiotic Resistance in Bacterial Pathogens

University of Southampton

Therapeutics and Diagnostics group

Project Description

Antimicrobial Resistance (AMR) is one of the most serious health threats globally and it is predicted that AMR bacteria will kill >10 million people by 2050. Recent advances in understanding antibiotic resistance mechanisms have suggested a potential therapeutic approach to overcome intrinsic antibiotic resistance. For this project, the successful candidate will combine biochemical, structural and microbiological studies, including characterisation of changes to the membranes of resistant bacteria, enzyme biochemistry, structural biology and inhibitor screening to better understand resistance mechanisms and to discover novel approaches to overcoming the threat of resistant bacteria.

The successful applicant will gain multidisciplinary expertise across the areas of chemical biology, biochemistry and microbiology, with opportunities for work placements in the collaborating laboratories at Public Health England and DSTL (both at Porton Down) respectively. For this project, we are seeking an enthusiastic graduate with at least a 2:1 degree in Chemistry, Biochemistry or a related biological discipline. The studentship is open to UK Nationals.

If you wish to discuss any details of the project informally, please contact Prof. Peter Roach, Chemical Biology, Therapeutics and Diagnostics group in Chemistry:

Supervisory Team: Prof. Peter Roach

Email: [email protected]

Tel: +44 (0) 2380 595919

Funding Information

Full tuition fees for UK students plus for UK students, an enhanced stipend of £15,285 tax-free per annum for up to 3.5 years.

Eligibility Requirements

A very good undergraduate degree (at least a UK 2:1 honours degree in Chemistry, Biochemistry or a related biological discipline.

Application Process

Applications should be made online, please select the academic session 2021/22 “PhD Chemistry (Full time)” as the programme. Please enter Peter Roach under the proposed supervisor.

Applications should include:

  • Curriculum Vitae
  • Two reference letters
  • Degree Transcripts to date

Apply online here

For further information please contact: [email protected]

Applications should be received no later than 31 August 2021 for standard admissions, but later applications may be considered depending on the funds remaining in place.

Supplementary Information

Equality, Diversity and Inclusion is central to the ethos in Chemistry. In recognition of our continued commitment to improving equality for women in science we were awarded an Athena SWAN Silver award in 2014 a and a second Silver award in 2017. Chemistry gives full consideration to applicants that wish to work flexibly including part-time. For further information please visit here.

The University of Southampton is in the top 1% of world universities and in the top 10 of the UK’s research-intensive universities. The University of Southampton is committed to sustainability and being a globally responsible university and has recently been awarded the Platinum EcoAward. Our vision is to embed the principles of sustainability into all aspects of our individual and collective work, integrating sustainable development into our business planning, policy-making, and professional activities. This commits all of our staff and students to take responsibility for managing their activities to minimise harm to the environment, whether this through switching off non-essential electrical equipment or using the recycling facilities.

*subject to qualifying criteria

To apply for this PhD, please use the following application link: https://www.southampton.ac.uk/courses/how-to-apply/postgraduate-applications.page

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