Investigating the structural and molecular mechanisms of male fertility by cryo EM
Project Description In this project you will study the structure and function of macromolecular complexes found in male Drosophila seminal fluid that are essential for fertility. Working at the Astbury Centre, University of Leeds, UK, you will solve structures of these complexes using cutting edge structural biology techniques (cryo electron microscopy, cryo electron tomography, cryo […]
A novel approach to the generation and optimisation of sustainable powders for Metal Additive Manufacturing
Project Description 3 Years full time 1st April 2021, 1st July 2021 or 1st October 2021 This PhD project will ignite an exciting new research area for the sustainable production, consumption and recycling of metallic materials for use in Metal Additive Manufacturing (AM) processes. Building on a strong track-record of AM research at Cardiff University, […]
Micro-manufacturing of surface textures for enhanced electrosurgery
Project Description 3 years full time 1st April 2021, 1st July 2021 or 1st October 2021 Electrosurgery is a medical procedure that uses an alternating and high frequency current (200 kHz-3.3 MHz) to either cut and/or coagulate tissues and achieve haemostasis. The technology faces a fundamental problem: tissue builds up on the electrodes of the […]
Improving Electric Vehicles’ Safety and Security through Cyber Situational Awareness
Project Description Context: To reduce greenhouses gases from the largest emitting sector, electric vehicles (EVs) present great opportunities for country like UK. Air pollution, which is considered as the second largest cause of death in UK, can be reduced using EVs. EVs can play a big role in achieving the decarbonization targets by UK. The […]
Estimate Cyber Risks for Electric Vehicle Infrastructure
Project Description Currently there is an urgent need for a sustainable digital route to zero-carbon road transport by facilitating low-carbon charging of electric vehicles (EVs) to meet the 2030 target to ban all new petrol and diesel cars, and 2050 Net-Zero. The UK government has announced £80 million ($99.7m) of investment to develop the next […]
Cyber Resiliency of Electric Vehicle Infrastructure
Project Description Cyber resiliency is one of the key requirements for constantly fighting against cyber-attacks on critical infrastructure. Research community as well as industry have realised that providing cyber resiliency is one of the key challenges as of now. It is a great need for more and better electric vehicle (EV) infrastructure that can offer […]
Cyber Incident-Response of Electric Vehicle Infrastructure
Project Description Context: Advanced cyber-attacks can massively disrupt the physical systems such electric vehicle (EV) infrastructure. It is not always possible to protect the system against potential threats and the available detection capabilities may not be enough. Therefore, it is vital to understand that the system is under attack, its potential impact and react with […]
Development of a novel calcium-based hydraulic sealer
Project Description Root canal therapy is necessary when the dental pulp is damaged irreversibly and has to be removed. The loss of the dental pulp creates a dead space inside the tooth which is colonized by bacteria. The aim of root canal therapy is to clean and shape the root canal after the dental pulp […]
Virus pathogenesis: interplay between the unfolded protein response and innate immunity.
Project Description The unfolded protein response (UPR) is a cellular homeostatic response in restoring endoplasmic reticulum balance upon stress conditions e.g. virus infections. It is an evolutionary conserved tripartite response. However, the evolution of the UPR has continuously been shaped by the arms race between virus and the host. For some viruses the UPR has […]
The functions of the Class II Pi3-kinase signals in vivo
Project Description Phosphoinositide lipids (PIPs) play critical roles in development and the homeostasis of adult tissues and their dysfunction has been linked to major human diseases such as cancer, diabetes, myopathies and neuropathies. We are working on an enzyme called the Class II Pi3K which generates two distinct PIP species: PI3P and PI(3,4)P2. While roles […]
