Microfluidic fabrication of nanoparticles/liposomes for drug delivery

University of Sheffield

Department of Chemical & Biological Engineering

Project Description

Microfluidic devices offer precise control of mixing multiple fluids in microscale, enabling fabrication of advanced micro/nanoparticles/liposomes with tunable structures and compositions in a high throughput and repeatable manner. The combination of these remarkable features with carefully selected materials and fabrication conditions enable high efficiency, direct encapsulation of actives in particles/liposomes with well controlled functionalities. These particles/liposomes have great potential in biomedical applications including drug delivery, cell-laden matrices, biosensors etc.

This PhD project is to use a newly designed microfluidic device to fabricate/formulate/functionalize micro/nanoparticles/liposomes for drug and gene delivery. The student will be trained to use the microfluidic device for particle fabrication, to use modern techniques such as AFM, SEM, TEM, FTIR, Dynamic Light Scattering (DLS)/nanosight, Circular Dichroism Spectroscopy (CD) to characterize the properties of the particles and to use Flow Cytometry, Confocal Laser Scanning Microscopy (CLSM) etc. to evaluate the drug and gene delivery efficacy.

Funding Information

Enquiries are welcomed from self-funded students (fees: View Website). Candidates should have a 1st class or 2.1 degree or MSc (merit or distinction) in physics, chemistry, materials, pharmacy, chemical engineering, or a related discipline.

For scholarship competition, candidates need a good 1st class to be competitive (or a GPA > 3.7/4.0 from a good international university). Applications should be submitted online before the end of each year.

Eligibility Requirements

If English is not your first language, you must have an IELTS certificate with an average of 6.5 or above and at least 6.0 in each component.

Application Process

All applications should be made online:
View Website

To apply for this PhD, please use the following application link: https://www.sheffield.ac.uk/postgraduate/phd/apply/applying

Overview
Location